2024 Can lexapro cause microscopic colitis

Microscopic colitis. Microscopic colitis is an inflammatory disease of the colon that causes chronic, watery, non-bloody diarrhoea. 1 Patients often experience between 4 and 9 watery stools per day, but in rare cases, this number can exceed 15. 1,2. Whilst the origin of microscopic colitis is largely unknown, it is likely to be multifactorial.. Ovavpzeag

May 15, 2018 · Background and Aims. Mood may have an important role in the natural history of inflammatory bowel disease (IBD). However, the impact of antidepressant use on prognosis is unknown. We aimed to address this in a longitudinal study in a referral population. Methods. We collected demographic data, clinical disease activity and mood using validated questionnaires, and antidepressant ... Lexapro for Anxiety User Reviews. Lexapro has an average rating of 7.5 out of 10 from a total of 885 reviews for the treatment of Anxiety. 68% of reviewers reported a positive experience, while 17% reported a negative experience. Filter by condition. Dec 1, 2022 · This section describes the typical Lexapro dose. The recommended dosage is the same for major depressive disorder and generalized anxiety disorder. The typical dosage range is 10 milligrams (mg ... Advise patients that taking Lexapro can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure glaucoma. Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Open-angle glaucoma is not a risk ...Lexapro for Anxiety User Reviews. Lexapro has an average rating of 7.5 out of 10 from a total of 885 reviews for the treatment of Anxiety. 68% of reviewers reported a positive experience, while 17% reported a negative experience. Filter by condition.Feb 21, 2023 · diarrhea. constipation. sexual side effects, such as: low sex drive. delayed ejaculation. difficulty reaching orgasm. mild allergic reaction *. Mild side effects of many drugs may go away within a ... Low sodium levels in the blood that may be serious and may cause death can happen during treatment with Lexapro. Elderly people and people who take certain medicines may be at greater risk for developing low sodium levels in the blood. Signs and symptoms may include: headache ; problems concentrating or thinkingJul 9, 2023 · This medicine can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use Lexapro (escitalopram solution) with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. A certain cause–effect relationship between drug exposure and microscopic colitis has only been ...One thing you don’t want to do is stop taking the medication without doctor supervision because of unwanted weight gain. Getty Images. 6. You may feel dizzy and drowsy. Lexapro also puts you in ...7 Facts from our Lexapro Review. Location: North Chicago, Illinois. Products: Lexapro is the brand name of an antidepressant called escitalopram. Costs: $490 for 30 10-mg tablets; may be covered by insurance or the manufacturer’s patient assistance program. Results: Effective in treating anxiety and depression.1- My very real struggle with postpartum depression/post-weaning anxiety. (May 2019) 2- Postpartum depression and anxiety update. (August 2019) I’ve lost count of the sweet mamas who have reached out to me over the past year who were also experiencing PPD or post-weaning depression. Many of you have also had great Lexapro success as well ...Lexapro has an average rating of 7.5 out of 10 from a total of 2283 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. Trintellix has an average rating of 5.9 out of 10 from a total of 1084 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. Microscopic colitis. Microscopic colitis is an inflammatory disease of the colon that causes chronic, watery, non-bloody diarrhoea. 1 Patients often experience between 4 and 9 watery stools per day, but in rare cases, this number can exceed 15. 1,2. Whilst the origin of microscopic colitis is largely unknown, it is likely to be multifactorial. Aug 20, 2022 · Escitalopram is a prescription drug used to treat depression and generalized anxiety disorder. Side effects may include taste alterations, shaking, fever, weight loss, weight gain, and headache. Learn drug interactions, dosage, and pregnancy and breastfeeding safety information. Lexapro (escitalopram oxalate) Tablets/Oral Solution NDA 21-323/NDA 21-365 Proposed Labeling Text . responded during an initial 8-week, open-label treatment phase with Lexapro 10 or 20 mg/day, were randomized to continuation of Lexapro at their same dose, or to placebo, for up to 36 weeks of observation for relapse.Lexapro for Depression User Reviews. Lexapro has an average rating of 7.2 out of 10 from a total of 575 reviews for the treatment of Depression. 63% of reviewers reported a positive experience, while 18% reported a negative experience. Filter by condition.Escitalopram (marketed as Lexapro) is included in the class of drugs called selective serotonin reuptake inhibitors (SSRIs). This class of drugs is used to treat depression, anxiety, and other ...A flexible-dose trial of Lexapro (10 to 20 mg/day) demonstrated the effectiveness of Lexapro [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of three weeks. Adults . The recommended dose of Lexapro is 10 mg once daily. A fixed-dose trial of Lexapro demonstrated the effectiveness of both 10 mg The most common symptoms of Lexapro withdrawal—occurring in more than one in four people—are: Dizziness. Muscle tension. Chills. Confusion. Trouble concentrating. Trouble remembering things. Crying. Dizziness, muscle tension, and chills each affect about 44% of people discontinuing Lexapro.Apr 21, 2021 · Lexapro is available in 5, 10, or 20 mg tablets (brand or generic) and as a liquid in 5 mg/5 ml oral solution (generic). This prescription medication costs are about $379 for 30 tablets of 10 mg brand name tablets. Most health insurance companies will cover the expenses of treatment with Lexapro. As brand-name drugs, Lexapro can be quite pricey. As noted, both medications block serotonin reuptake in the body, leading to increased levels of the neurotransmitter. 1. While Lexapro and Zoloft work in the same ways, they each have different chemical compositions and associated side effects. A prescriber will determine which medication is better suited for a patient.Background and Aims. Mood may have an important role in the natural history of inflammatory bowel disease (IBD). However, the impact of antidepressant use on prognosis is unknown. We aimed to address this in a longitudinal study in a referral population. Methods. We collected demographic data, clinical disease activity and mood using validated questionnaires, and antidepressant ...Jan 18, 2017 · A certain cause–effect relationship between drug exposure and microscopic colitis has only been ... The issue of drug-induced microscopic colitis is important because of the burden of this disease. Thus, any case that can be cured by withdrawal of a drug must be identified. In this report, we propose a scoring system for drug-induced microscopic colitis, adapting existing criteria of drug causality, and review the literature using this framework.Lexapro can sometimes cause episodes of mania, especially for patients with undiagnosed bipolar disorder. Panic attacks : Common symptoms of a panic attack include chest pain , shortness of breath , hyperventilation, trembling or shakiness, nausea , and sweating.May 13, 2020 · Wellbutrin and Lexapro affect the levels of different neurotransmitters. While their potential to cause certain side effects may be similar, there are some key differences. Lexapro, like other SSRIs, has the potential to cause decreased libido or sex drive. Wellbutrin had no reported incidence of decreased libido. Precautions. It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to help reduce any side effects. Blood tests may be needed to check for any unwanted effects. Do not take escitalopram with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid (Zyvox ...Lexapro for Anxiety User Reviews. Lexapro has an average rating of 7.5 out of 10 from a total of 885 reviews for the treatment of Anxiety. 68% of reviewers reported a positive experience, while 17% reported a negative experience. Filter by condition. Lexapro; Canadian Brand Name. ACT-Escitalopram ODT; Descriptions. Escitalopram is used to treat depression and generalized anxiety disorder (GAD). It is an antidepressant that belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines work by increasing the activity of the chemical serotonin in the ...Suicidality. antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds pts . 7 yoLexapro Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi-ingredient medications may also be listed when applicable. What does Lexapro look like?Jun 28, 2022 · swelling of your face, tongue, eyes, or mouth. rash, itchy welts ( hives ), or blisters (alone or with fever or joint pain) Hives. seizures or convulsions. suicidal thoughts and behaviors ... Background and Aims. Mood may have an important role in the natural history of inflammatory bowel disease (IBD). However, the impact of antidepressant use on prognosis is unknown. We aimed to address this in a longitudinal study in a referral population. Methods. We collected demographic data, clinical disease activity and mood using validated questionnaires, and antidepressant ...Jan 17, 2023 · Escitalopram (Lexapro) is available as both a tablet and a liquid. Some people notice an improvement in their condition as early as a week after they start treatment. Some common side effects of escitalopram (Lexapro) include nausea, trouble sleeping, and drowsiness. For some people, these side effects go away or lessen over time. Low sodium levels in the blood that may be serious and may cause death can happen during treatment with Lexapro. Elderly people and people who take certain medicines may be at greater risk for developing low sodium levels in the blood. Signs and symptoms may include: headache ; problems concentrating or thinkingLexapro is available in 5-, 10- and 20-milligram tablets and can be taken in the morning or at night, with or without food. It is also available as an oral solution with doses varying by the ...May 5, 2010 · The incidence of microscopic colitis (MC) is increasing, but its etiology remains unknown. Case reports and limited controlled data suggest that commonly prescribed drugs may be triggers. The aim of this study was to evaluate the prevalence of selected medication use [Proton pump inhibitors (PPIs), HMG-CoA reductase inhibitors (statins), and ... Aug 1, 2023 · Precautions. It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to help reduce any side effects. Blood tests may be needed to check for any unwanted effects. Do not take escitalopram with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid (Zyvox ... Jul 9, 2023 · This medicine can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use Lexapro (escitalopram solution) with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. Jun 28, 2022 · swelling of your face, tongue, eyes, or mouth. rash, itchy welts ( hives ), or blisters (alone or with fever or joint pain) Hives. seizures or convulsions. suicidal thoughts and behaviors ... sweating, dry mouth, increased thirst, loss of appetite; nausea, constipation; yawning; nosebleed, heavy menstrual periods; or. decreased sex drive, impotence, or difficulty having an orgasm. This ...Others may notice the medication kicking in within 1 to 3 weeks of treatment initiation. Within 8 weeks: It is estimated that over 80% of Lexapro users will report the medication working within 4 to 8 weeks of administration. If you don’t notice Lexapro working in the early days or weeks of treatment, understand that 8 weeks may be needed for ...Low sodium levels in the blood that may be serious and may cause death can happen during treatment with Lexapro. Elderly people and people who take certain medicines may be at greater risk for developing low sodium levels in the blood. Signs and symptoms may include: headache ; problems concentrating or thinkingOct 20, 2022 · Although it is rare, Lexapro may cause severe allergic reactions, which can result in: trouble breathing. wheezing. swelling of the face, tongue, mouth, or throat. itching. rash, hives, or ... Lexapro’s effect on weight. Lexapro can cause changes in weight. There are some reports that people begin to lose weight when first taking Lexapro, but this finding is not well supported by ...Aug 15, 2023 · The main differences between Celexa and Lexapro are: Celexa is a branded version of citalopram and Lexapro is a branded version of escitalopram. Citalopram is a mixture of two stereo-isomers: R-citalopram and S-citalopram. Stereo-isomers are compounds that have the same chemical formula but differ only in their arrangement of atoms. Posted 5/6/2009 10:10 PM (GMT -8) Up until 2002 my bowel motions were normal, then I started taking Paxil in 2002 and almost immediately my bowel motions changed. I had more gas and bloating and the stool moved quicker through my intestine. It didnt worry me too much but now i have UC I'm wondering if the anti-depressant was the original cause.Mar 25, 2021 · Background. Microscopic colitis (MC) is a chronic inflammatory condition of the colon, predominantly subdivided into collagenous colitis (CC) and lymphocytic colitis (LC). Microscopic colitis typically presents as chronic, nonbloody diarrhea with an endoscopically and radiologically normal colon but which demonstrates inflammatory changes on ... Lexapro is well-absorbed by the body regardless of whether you take it with food. This means you can take Lexapro without food, or without food — whichever works for you. In clinical studies, about 15% of people taking Lexapro experienced nausea. If you find that you feel nauseated after taking Lexapro, you can try taking it with food. 3.Jul 5, 2023 · The most common effect of Lexapro is an improvement in mood. However, it’s still possible to experience side effects. Common side effects include: Decreased energy levels. Trouble sleeping. Decreased sex drive (difficulty with orgasm, loss of interest in sexual intercourse) Constipation or diarrhea. Dry mouth. Escitalopram (marketed as Lexapro) is included in the class of drugs called selective serotonin reuptake inhibitors (SSRIs). This class of drugs is used to treat depression, anxiety, and other ...clumsiness or unsteadiness. hair loss or thinning of the hair. increased sensitivity of skin to sunlight. lack or loss of strength. red irritated eyes. red skin lesions, often with a purple center. redness or other discoloration of the skin. severe sunburn. Other side effects not listed may also occur in some patients.There is no specific time that is best to take it. However, a person experiencing insomnia may want to schedule Lexapro for the morning. Lexapro, the brand name for the antidepressant escitalopram ...Jan 20, 2021 · This exam allows your doctor to view your entire colon using a thin, flexible, lighted tube (colonoscope) with an attached camera. The camera sends images of your rectum and entire colon to an external monitor, allowing your doctor to examine the intestinal lining. Severe side effects can occur with Lexapro, like high blood pressure, also known as hypertension. Lexapro also may cause serotonin syndrome, characterized by symptoms that include agitation, fever, hallucinations, diarrhea, heartbeat irregularities, and restlessness. If that happens, contact your doctor immediately.Nov 8, 2021 · sweating, dry mouth, increased thirst, loss of appetite; nausea, constipation; yawning; nosebleed, heavy menstrual periods; or. decreased sex drive, impotence, or difficulty having an orgasm. This ... A flexible-dose trial of Lexapro (10 to 20 mg/day) demonstrated the effectiveness of Lexapro [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of three weeks. Adults . The recommended dose of Lexapro is 10 mg once daily. A fixed-dose trial of Lexapro demonstrated the effectiveness of both 10 mg Lexapro; Canadian Brand Name. ACT-Escitalopram ODT; Descriptions. Escitalopram is used to treat depression and generalized anxiety disorder (GAD). It is an antidepressant that belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines work by increasing the activity of the chemical serotonin in the ...Microscopic colitis. Microscopic colitis is an inflammatory disease of the colon that causes chronic, watery, non-bloody diarrhoea. 1 Patients often experience between 4 and 9 watery stools per day, but in rare cases, this number can exceed 15. 1,2. Whilst the origin of microscopic colitis is largely unknown, it is likely to be multifactorial.Escitalopram (Lexapro) is available as both a tablet and a liquid. Some people notice an improvement in their condition as early as a week after they start treatment. Some common side effects of escitalopram (Lexapro) include nausea, trouble sleeping, and drowsiness. For some people, these side effects go away or lessen over time.Lexapro has an average rating of 7.5 out of 10 from a total of 2283 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. Trintellix has an average rating of 5.9 out of 10 from a total of 1084 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect.sweating, dry mouth, increased thirst, loss of appetite; nausea, constipation; yawning; nosebleed, heavy menstrual periods; or. decreased sex drive, impotence, or difficulty having an orgasm. This ...Lexapro (escitalopram) and Paxil (paroxetine) are selective serotonin reuptake inhibitor (SSRI) antidepressants used to treat depression. Lexapro is also used to treat anxiety disorders. Side effects of Lexapro and Paxil that are similar include nausea, headaches, diarrhea, difficulty sleeping (insomnia), drowsiness, dry mouth, increased sweating, and changes in appetite.Citalopram belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). A common brand name for citalopram is Celexa®. Escitalopram contains the same active medication as citalopram. These two drugs act in the body in a very similar way. Escitalopram is used to treat depression and generalized anxiety disorder.Lexapro is the trademark name for the generic drug escitalopram, an antidepressant medication. Like Zoloft (sertraline), it is a selective serotonin reuptake inhibitor (SSRI) that was introduced in the late 1980s. Available in pill or liquid form, it's prescribed to treat a variety of mental health conditions, such as depression and anxiety.Colitis microscopic is found among people who take Lexapro, especially for people who are female, 30-39 old, have been taking the drug for 5 - 10 years. The phase IV clinical study analyzes which people take Lexapro and have Colitis microscopic.The phase IV clinical study analyzes which people take Lexapro and have Ulcerative colitis. It is created by eHealthMe based on reports of 75,368 people who have side effects when taking Lexapro from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.The phase IV clinical study analyzes which people take Lexapro and have Ulcerative colitis. It is created by eHealthMe based on reports of 75,368 people who have side effects when taking Lexapro from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.See full list on mayoclinic.org Jan 18, 2017 · A certain cause–effect relationship between drug exposure and microscopic colitis has only been ... Lexapro; Canadian Brand Name. ACT-Escitalopram ODT; Descriptions. Escitalopram is used to treat depression and generalized anxiety disorder (GAD). It is an antidepressant that belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines work by increasing the activity of the chemical serotonin in the ...A flexible-dose trial of Lexapro (10 to 20 mg/day) demonstrated the effectiveness of Lexapro [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of three weeks. Adults . The recommended dose of Lexapro is 10 mg on ce daily. A fixed-dose trial of Lexapro de monstrated the effectiveness of both 10There are some differences in their side effects with Lexapro being more likely to cause sleep problems and taste disturbances, and Zoloft is more likely to cause skin rash or diarrhea. There is some evidence that Lexapro may be more effective than other SSRIs, including Zoloft, in the treatment of depression.Abdominal pain. Somnolence (drowsiness) Rhinitis (nasal congestion) Changes in appetite. Increased sweating from Lexapro. Lexapro can also cause side effects that affect your sexual functioning, including a low level of sexual desire and anorgasmia (delayed, infrequent or absent orgasms).Dec 1, 2022 · This section describes the typical Lexapro dose. The recommended dosage is the same for major depressive disorder and generalized anxiety disorder. The typical dosage range is 10 milligrams (mg ... The recommended dose of Lexapro is 10 mg once daily. A fixed-dose trial of Lexapro demonstrated the effectiveness of both 10 mg and 20 mg of Lexapro, but failed to demonstrate a greater benefit of 20 mg over 10 mg [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of one week. Maintenance TreatmentRisks, Side Effects and Black Box Warning. Lexapro and Celexa can cause common side effects. These include nausea, insomnia, sweating, dry mouth and drowsiness. Such side effects are likely to go away as the body adjusts to taking medication. Other common sexual side effects rarely diminish over time. See full list on mayoclinic.org

Escitalopram. Escitalopram, sold under the brand names Lexapro and Cipralex, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [4] Escitalopram is mainly used to treat major depressive disorder and generalized anxiety disorder. [4] It is taken by mouth, [4] available commercially as an oxalate salt .... Oraltube300x250.gif

Jun 28, 2022 · swelling of your face, tongue, eyes, or mouth. rash, itchy welts ( hives ), or blisters (alone or with fever or joint pain) Hives. seizures or convulsions. suicidal thoughts and behaviors ... The mix of alcohol and Lexapro can lead to more side effects than from taking Lexapro by itself. Together, the two can make you feel: Drowsy. Less alert. Less coordinated. In extreme cases ... Risks, Side Effects and Black Box Warning. Lexapro and Celexa can cause common side effects. These include nausea, insomnia, sweating, dry mouth and drowsiness. Such side effects are likely to go away as the body adjusts to taking medication. Other common sexual side effects rarely diminish over time.Some dosage forms listed on this page may not apply to the brand name Lexapro. Summary. Common side effects of Lexapro include: diarrhea, drowsiness, ejaculatory disorder, headache, insomnia, nausea, and delayed ejaculation. Other side effects include: anorgasmia, constipation, dizziness, dyspepsia, fatigue, decreased libido, diaphoresis, and ...Lexapro (escitalopram oxalate) Tablets/Oral Solution NDA 21-323/NDA 21-365 Proposed Labeling Text . responded during an initial 8-week, open-label treatment phase with Lexapro 10 or 20 mg/day, were randomized to continuation of Lexapro at their same dose, or to placebo, for up to 36 weeks of observation for relapse. Also, irritable bowel conditions like IBS, Crohn’s ulcerative colitis and celiac disease, which can cause similar symptoms can cause bleeding into the gut which is not visible to naked eye. So, an occult stool test should be done apart from stool routine and microscopic for ova and cysts of parasites. If these tests are not conclusive, then ...Escitalopram. Escitalopram, sold under the brand names Lexapro and Cipralex, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [4] Escitalopram is mainly used to treat major depressive disorder and generalized anxiety disorder. [4] It is taken by mouth, [4] available commercially as an oxalate salt ...Wait 14 days after stopping escitalopram before you start taking a MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures.Risks, Side Effects and Black Box Warning. Lexapro and Celexa can cause common side effects. These include nausea, insomnia, sweating, dry mouth and drowsiness. Such side effects are likely to go away as the body adjusts to taking medication. Other common sexual side effects rarely diminish over time. Escitalopram is also used to treat generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults, teenagers, and children 7 years of age and older. Escitalopram is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). Lexapro obstructs the re-absorption of serotonin into the first cell, which causes an increased amount of serotonin to end up being readily available. Lexapro Benefits for Depression. Depression and anxiety can be devastating, preventing many patients from working totally in life and leaving an influence on their families.Aug 15, 2023 · The main differences between Celexa and Lexapro are: Celexa is a branded version of citalopram and Lexapro is a branded version of escitalopram. Citalopram is a mixture of two stereo-isomers: R-citalopram and S-citalopram. Stereo-isomers are compounds that have the same chemical formula but differ only in their arrangement of atoms. Jan 25, 2023 · As noted, both medications block serotonin reuptake in the body, leading to increased levels of the neurotransmitter. 1. While Lexapro and Zoloft work in the same ways, they each have different chemical compositions and associated side effects. A prescriber will determine which medication is better suited for a patient. Aug 14, 2022 · Lexapro is the trademark name for the generic drug escitalopram, an antidepressant medication. Like Zoloft (sertraline), it is a selective serotonin reuptake inhibitor (SSRI) that was introduced in the late 1980s. Available in pill or liquid form, it's prescribed to treat a variety of mental health conditions, such as depression and anxiety. Lexapro (escitalopram oxalate) Tablets/Oral Solution NDA 21-323/NDA 21-365 Proposed Labeling Text . responded during an initial 8-week, open-label treatment phase with Lexapro 10 or 20 mg/day, were randomized to continuation of Lexapro at their same dose, or to placebo, for up to 36 weeks of observation for relapse. .

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